AT 1000 TB is an all-natural medicine with a synergistic combination of biomeds which have Analgesic, Cartilage-protective and regenerative activity. The medicine is targeted at the treatment of Rheumatoid arthritis, Osteoarthritis, Osteoporosis, Joint degeneration, Cervical Spondylitis.
Component 1: Moringa oleifera
Kaempferol-3-glucoside: Potent anti-inflammatory action
Chlorogenic acid: Potently inhibits prostaglandins, especially the endoperoxidase; exhibits antinociceptive and anti-inflammatory activity; primary role as an analgesic
Component 2: Curcuma longa
Active biomolecule: Curcumin
Exhibits potent anti inflammatory and analgesic effect by :
1) Inhibiting PGE2 production via the inhibition of COX-2 gene expression,
2) Stimulating cortisol production by adrenal gland by inhibiting the bTREK-1 potassium channels,
3) Depleting nerve endings of the neurotransmitter substance P
Component 3: Boswellia serrata
Active biomolecule: Acetyl-11-keto-β-boswellic acid
Analgaesic activity by Acetyl-11-keto-β-boswellic acid which is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. Decreased degradation of Glycosaminoglycans, prevents destruction of Articular cartilage
Component 4: Cissus quadrangularis
Contains natural Calcium oxalate, Ascorbic acid, β-sitosterol and 3-ketosteroids.
Calcium and natural Anabolic ketosteroids Amyrin and Amyrone promote biomineralization of Bones through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts.
Inhibits gene expression of Cytokines and Matrix metalloproteinases, known to aggravate cartilage and bone destruction, and augmented expression of Survivin by inhibiting p38 MAPK
Phytoestrogens and polyphenolic compounds along with Ascorbic acid accelerates fracture healing
Beta-sitosterol, d--amyrin, and d-amyrone inhibit IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration.
Enriched with Glucosamine: Glucosamine sulfate decreases ADAMTS5 expression and reduces significantly IL-1β-induced pro-MMP1 secretion and various anti-inflammatory properties in main tissues involved in OA: cartilage, synovial membrane and subchondral bone. Stimulates production of Aggrecan and Proteoglycans which repair and prevents cartilage degradation.
Glucosamine reduces interleukin-1 (IL-1) levels in synovial fluid and inhibits the actions of catabolic enzymes in the joint, This reduces inflammation and cartilage degradation potentially altering the progression of OA.
Enriched with Guggulsterone (which inhibits activation of Nuclear factor-êB, Anti inflammatory effect. Potent Anti osteo clastogenic activity prevents bone loss), Friedelin (which inhibits PG synthesis, Anti-inflammatory and Analgesic activities. Vit C & Carotene stabilizes Synovial membrane), Phyto Sterols (which exhibits analgesic action via nervous system modulation), Pluchine (which is potent Smooth muscle relaxant and Spasmolytic), Thiocolchicoside (which binds to g-amino-butyric acid (GABA) receptor acts as a potent muscle relaxant), Sitosterol, Quercitin, Gallic Acid (the trio exhibits potent Anti inflammatory & Analgesic Action).
Contains Withanolide D (which has Anti-inflammatory and Anti collagenase activities ,exhibit chondroprotective effect), Fulvic acid (which promotes Osteoblast activity, preserving cartilage), 82 minerals in ion form promote cartilage regeneration.
Natural Gingerol inhibits Cyclooxygenase (COX), Lipo-oxygenase, in Synoviocytes and protects Synovial membrane.
No long term side effects
Overdose of medicine may lead to constipation and irregular or uncomfortable bowel movements
Overdose may lead to nausea